The human translational research cohort (T cohort)

Publié le 22/05/2020 à 15h10

The most important INSPIRE research cohort will be made of 1,000 people from 20 years old to the most advanced age. Participants are seen once a year at the Clinical Research Center of the Gerontopole where geriatricians proceed with a thorough evaluation of their functions following the ICOPE guidelines and several biological samplings (cf. Chart 1). For a sub-sample of the participants, some complementary tests are offered such as MRI, DEXA, exercise test (VO2 max) & measurement of muscular strength (Cybex). Between annual appointments, every 4 months, participants will be asked to monitor themselves with the ICOPE MONITOR application. According to the observed results, a more in-depth evaluation may be suggested in order to research the potential causes of a decline (including biological, environmental, social causes and intercurrent diseases) and propose specific and bespoke prevention strategies.

In order to determine links between geroscience and Alzheimer Disease, researchers will study plasmatic markers as predictive of Alzheimer Disease.

T-cohort ancillary study : CART / SMART HOME

CART (or Smart Home), is a study that will be carried out in a sub-group of the INSPIRE translational research cohort, to obtain more refined data on activity and mobility using sensors installed at home. Approximately 100 participants’ homes will be equipped during the period covering the project. This study is carried out in partnership with the University of Portland in Oregon (USA) where these sensors have led to scientific advances over the last 10 years.

Other digital tools will enrich the panel used to date. Thalès and EDF companies, for example, propose measurement technologies that could also be implemented within sub-groups of the T-cohort in the future.